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Information on duration of oral oestrogen use was available in only five case-control studies.

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At five years, 75% of the women adhered to the randomisation arm to which they were allocated for 80% or more of the time.

Different hormone replacement therapy regimens have been found to have positive effects on lipid metabolism and the combination 17-β-estradiol with norethisterone acetate has been shown to lower total cholesterol levels and improve endothelial function in healthy postmenopausal women.

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By comparison, our study had more than twice the number of VTE cases; added a further four years of data; adjusted for body mass index, smoking status, alcohol consumption, ethnic group, several chronic and acute conditions associated with increased VTE risk, and use of other hormonal contraceptives; and accounted for age, calendar year, and practice by matching.

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Antifibrinolytic agents, such as tranexamic acid and ε-aminocaproic acid, can be effective nonhormonal treatment options for adolescents; however, their use in individuals younger than 18 years is considered “off-label.

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